Jerry Iowa introduces Fred McLafferty, a legendary figure in the field of mass spectrometry. McLafferty is known for his pioneering work in environmental chemistry, particularly in identifying unknown pollutants using mass spectrometry techniques. He has contributed significantly to the development of top-down proteomics and has published numerous influential papers in the field. McLafferty’s most recent work involves a top-down technique for analyzing large proteins, including those up to 200 kilodaltons in size. He also developed a mass marker for use in mass spectrometry analysis and was instrumental in the development of the first real separator for mass spectrometry. McLafferty’s work has been crucial in identifying molecules in the mass spectrometer and has helped to establish mass spectrometry as a powerful tool for structure determination.